Celine Arceneau was admitted to the hospital for food poisoning and declared medically stable before her physician, Ellen Smythe, left for the evening. When she died the next morning from an unknown cause, Chief Detective Stefan Jablonsky suspects foul play and eyes Dr. Smythe, Dr. Kate Chamber's friend and mentor, as his prime suspect. Pittsburgh's amateur sleuth quickly joins the fight to prove her friend's innocence.

Chief Detective Jablonsky and Kate Chambers have worked together in the past; he finds her and her university friends to be elitist and annoying, but grudgingly effective, and she finds him to be a stodgy, old-school detective, but one who always gets the killer. Jablonsky and Kate must put aside their differences to catch the culprit before the body count rises.

This psychological mystery will hold you captive until the very end. Locked Box is the third book in the Pittsburgh Murder Mystery series: however, each book can be read as a stand-alone or in order of publication.