George's grandma is a grouch! She's always mean to George (and not much nicer to his parents, either). One day, when George is put in charge of giving Grandma her medicine, he wonders if he can come up with his own remedy to try and help Grandma become less of a grump. Using some rather unusual ingredients, George creates a magic medicine, a remedy for everything. But will it stop his grandma from being so horrible . . . or will it shoot sparks out of the top of her head?!