Up-and-coming stage actress Margaret Shoard has just taken a bow as Lady Macbeth, the role she has always believed was destined for her. At home, she plays wife to her best friend Wesley, even if she doesn't hold his sole attention romantically. After a public breakdown threatens all she holds dear, Margaret's doctor prescribes her uppers--just a little help to get through the days.

When Wesley is invited by eccentric director Vaughn Kline to join the cast for an inaugural Shakespeare performance in the New Mexico desert, Margaret decides to accompany him in hopes the time away will set her back to rights . . . but the world she finds in Vaughn's company is filled with duplicity and betrayal. Margaret and Wesley, embroiled in an affair with a man who may not be all he seems, must find a way forward together before their story becomes the real tragedy.