In a city so dismal it's known only as "the Hole," a clan of Sorcerers has been plucking people off the streets to use as guinea pigs for atrocious "experiments" in the black arts. In a dark alley, Nikaido found Caiman, a man with a reptile head and a bad case of amnesia. To undo the spell, they're hunting and killing the Sorcerers in the Hole, hoping that eventually they'll kill the right one. But when En, the head Sorcerer, gets word of a lizard-man slaughtering his people, he sends a crew of "cleaners" into the Hole, igniting a war between two worlds.

While En seeks out a new partner with unique magic powers, his crew has a run-in with an underground organization that controls the distribution of "black powder," a magic-enhancing drug used by weaker Sorcerers. Meanwhile, Caiman and Nikaido spend New Year's in the haunted mansion of a mysterious doctor who specializes in the anatomy of Sorcerers. The doctor reveals to them the only known portal to the Sorcerers' dimension...