In a city so dismal it's known only as "the Hole," a clan of Sorcerers has been plucking people off the streets to use as guinea pigs for atrocious "experiments" in the black arts. In a dark alley, Nikaido found Caiman, a man with a reptile head and a bad case of amnesia. To undo the spell, they're hunting and killing the Sorcerers in the Hole, hoping that eventually they'll kill the right one. But when En, the head Sorcerer, gets word of a lizard-man slaughtering his people, he sends a crew of "cleaners" into the Hole, igniting a war between two worlds.

Caiman's true face is revealed, shaking the entire world to its foundation! But have his memories disappeared along with his lizard head? The severely injured Nikaido's health is draining perilously, yet a chance encounter with a familiar figure may be just what she needs. Meanwhile, En may have met his ultimate match. What drives him? Many truths will come to light in this shocking installment of Dorohedoro!