In a city so dismal it's known only as "the Hole," a clan of Sorcerers has been plucking people off the streets to use as guinea pigs for atrocious "experiments" in the black arts. In a dark alley, Nikaido found Caiman, a man with a reptile head and a bad case of amnesia. To undo the spell, they're hunting and killing the Sorcerers in the Hole, hoping that eventually they'll kill the right one. But when En, the head Sorcerer, gets word of a lizard-man slaughtering his people, he sends a crew of "cleaners" into the Hole, igniting a war between two worlds.

With success almost in his grasp for once, Fujita is forced to strike a desperate, dangerous deal with Tetsujo, last survivor of the slaughtered Cross-Eyes. Meanwhile, En's former "cleaners" Shin and Noi venture through the Central Department Store to try and resurrect their boss. And Ebisu ... well, she's just doing Ebisu stuff. All the while, Nikaido continues to manifest stranger and stranger powers under the guidance of former Devil Asu.