"Bloody" Mary, a vampire with a death wish, has spent the past 400 years chasing down a modern-day exorcist named Maria who is thought to have inherited "The Blood of Maria" and is the only one who can kill Mary. To Mary's dismay, Maria doesn't know how to kill vampires. Desperate to die, Mary agrees to become Maria's bodyguard until Maria can find a way to kill him.

At the Sakuraba Estate, Maria and Shin discover the estate has been attacked by vampires. Meanwhile, hoping to rouse the immortal Yzak from his coma, Mary imbibes his blood, but the exorcist does not awaken. Weak and unstable, Mary stumbles back to find Maria but suffers from a bout of amnesia that leaves Maria shaken.