Dalmatians Pongo and Perdita have just become parents to fifteen lovely puppies. Everything is going great until one day wretched Cruella De Vil captures Pongo and Perdita's puppies, along with all the other Dalmatian pups in London! With the help of the Twilight Bark, and lots of great canine friends, Pongo and Perdita set out on an exciting journey to hunt down the evil pup-napper and rescue their little ones.