Upstate New York in the mid-19th century is a cauldron bubbling with the lure of fast fortunes, religious zealotry, and battles for civil liberties. This fervor centers on the Erie Canal, which successfully supports scores of villages brimming with opportunity. One such village, Fayetteville, shapes the lives of two future American leaders.

High Bridge tells the stories of a young newlywed, the only child of freethinking abolitionists, and a prankster lad who grows up in the large family of an austere reverend. Despite their different childhoods and worldviews, they form an unlikely friendship. Can they combine their skills to solve a mystery and vindicate a Black man accused of murder?