Agent Bishop's long-gestating hunt for mutants begins in earnest and no one is safe! The Mutanimals are the first targets, but the Turtles' turn will come soon enough, and they'll be hounded like never before. Alopex and Nobody are looking for a little rest and relaxation but get more than they ask for when they become the unwilling guests of a never-ending party thrown by the hedonistic Toad Baron! Plus, Karai has always embodied the Foot Clan. With the Clan under the control of Splinter, what path will she take during her travels in Japan? Danger and intrigue await her, Koya, and Bludgeon!

Collects issues #67-72 of the ongoing Teenage Mutant Ninja Turtles series, Teenage Mutant Ninja Turtles Universe issues #9-15, and the TMNT/Usagi Yojimbo crossover.