When burglars break into Hope Mausoleum and violate Crypt 1083-A, where the remains of the former Girod Street Cemetery are housed, New Orleans property crimes detective Thibodeaux "Bo" Duplessis is confronted with three confounding questions: Who are the burglars? Why did they break into the crypt? What, if anything, did they take?

In need of expertise he does not possess, Bo turns to his childhood friend Bruneau Abellard, a cranky, overweight antiques dealer with exacting epicurean standards and a font of historical knowledge. Affecting annoyance, though privately intrigued, Bruneau agrees to assist with Bo's case. Together, the friends uncover a secret love affair between a famous antebellum actress, whose remains are contained in the crypt, and the notorious pirate Jean Lafitte. As their investigation deepens, they find themselves confronting two separate yet entwined mysteries, two hundred years apart. To solve the present-day crime, they come to realize they must first unravel a conundrum from the distant, murky past.

Set against the singular backdrop of contemporary New Orleans, with glimpses of the city during its "Belle Epoque" of the 1820s, The Lafitte Affair is populated with characters as eccentric as the city itself: a grand dame of the Garden District; a competitive female puzzler; a slippery con man; a giant hermit with a shrouded past; a pugnacious French bulldog; and a phantom thief who seems always two steps ahead of his pursuers. Looming over them all is the ghostly presence of the pirate Lafitte, a larger-than-life figure of seemingly endless contradictions.