In September of 1890, the academic year begins at the Carlisle School, a military-style boarding school for Indians in Pennsylvania, founded and run by Captain Richard Henry Pratt. Pratt considers himself a champion of Native Americans. His motto, "To save the man, we must kill the Indian," is severely enforced in both classroom and dormitory: Speak only English, forget your own language and customs, learn to be white.

As the young students navigate surviving the school, they begin to hear rumors of a "ghost dance" amongst the tribes of the west--a ceremonial dance aimed at restoring the Native People to power, and running the invaders off their land. As the hope and promise of the ghost dance sweeps across the Great Plains, cynical newspapers seize upon the story to whip up panic among local whites. The US government responds by deploying troops onto lands that had been granted to the Indians. It is an act that seems certain to end in slaughter.

As news of these developments reaches Carlisle, each student, no matter what their tribe, must make a choice: to follow the white man's path, or be true to their own way of life . . .