Charleston divorce attorney Lisa "LeeLee" Moretz has a successful career, a beautiful family, and a coveted South of Broad address. But beneath the tranquil surface, her own marriage is crumbling. When her first love, Peace Smith, appears at her office with alarming news about her old friend Ginny Blankenship, LeeLee is catapulted into a missing-person case. She also realizes she's never truly gotten over Peace, who left town with Ginny a decade ago.

In high school, carefree daredevil Ginny makes no secret of her prophetic powers, but dark addictions are budding under her chaotic charm. When Ginny meets cautious new girl LeeLee, she's surprised to discover they share the ability to see into the future and the past. Ginny embraces LeeLee and draws her into a tight-knit circle of friends, including Peace, Ginny's charismatic but troubled boyfriend.

Now Peace has returned to the Lowcountry, but he's a prime suspect in Ginny's disappearance. LeeLee must uncover the truth about Ginny, and her own future hinges on Peace's innocence. Through LeeLee and Ginny's divergent life trajectories and complicated bond, Mean Low Water explores the power of lifelong relationships.