What would the world be like if 80 percent of the population manifested superpowers called "Quirks"? Heroes and villains would be battling it out everywhere! Being a hero would mean learning to use your power, but where would you go to study? The Hero Academy of course! But what would you do if you were one of the 20 percent who were born Quirkless?

The Hassaikai crime gang, led by the young boss Chisaki, has been working on a plan to distribute a Quirk-destroying drug. The key to this evil scheme is the young girl Eri, held prisoner in Chisaki's hideout. Nighteye asks other heroes to form a team to launch a rescue attempt--and the students of Class 1-A are going into the lion's den with them! But Nighteye, who can see the future, refuses to look at the fates of anyone on the mission...