In Taisho-era Japan, kindhearted Tanjiro Kamado makes a living selling charcoal. But his peaceful life is shattered when a demon slaughters his entire family. His little sister Nezuko is the only survivor, but she has been transformed into a demon herself! Tanjiro sets out on a dangerous journey to find a way to return his sister to normal and destroy the demon who ruined his life.

The Demon Slayer Corps plunges into Infinity Castle to confront Muzan. Shinobu engages in a fierce fight against Doma, the Upper Rank 2 demon. Poison doesn't work on him, so she finds herself in an intense struggle. Will she be able to defeat the demon who killed her older sister?! Then another demon appears before Zenitsu and blocks his way...