Jane is a wiz at facts and numbers, but she's clueless when it comes to other kids. Her autism and all-consuming love of cats make her a target for bullies. She's nothing like Ashley. Ashley is bubbly and excitable and has always been best friends with the queen bee of Monroe Elementary. When Ashley refuses to lie to keep her best friend out of serious trouble, she loses her seat at the popular table--and her whole identity along with it.

The one thing Jane and Ashley have in common is the best teacher in the world, Miss DiMicco. When Miss DiMicco is arrested after being accused of stealing at a school fundraiser, and a miserable sub takes her place, the girls form an unlikely alliance to clear their teacher's name. As they butt heads over cats, makeup, and the rules of sixth grade, the girls fight to get their teacher back and to keep their friendship from falling apart.