Fusco has been a leader in conversations around the intersection of identity, feminism, culture, and politics in the Americas and beyond. Emerging during the 1980s as a pioneering advocate of multiculturalism in the arts, Fusco utilizes performance, video, archival research, and writing to reflect upon the ways that intercultural relations and colonial histories shape the construction of the self and perceptions of cultural difference. Her work critically examines society from a postcolonial perspective, engaging with debates about cultural politics throughout the Americas, Europe, and elsewhere. This expansive approach is highlighted through a broad range of works that address themes including postrevolutionary Cuba, racial stereotypes, feminist politics, ethnographic displays, military interrogation, and sex tourism.