Years after the events of The House of God, the Fat Man has been given leadership over the new Future of Medicine Clinic at what used to be Man's Best Hospital but has sunk to an embarrassing 4th, and has persuaded Dr. Roy Basch and some of his cohorts to join him in teaching a new generation of interns and residents. In a medical landscape dominated by computer screens and corrupted by money, they have one goal: to make medicine humane again.

What follows is a mesmerizing, heartbreaking, and hilarious exploration of how the health-care industry, and especially doctors, have evolved over the past thirty years.