When a portrait is lost that has maintained Quentin Collins's youthful appearance for over a century--and has also kept his werewolf curse at bay--Quentin begins to dread the full moon.

Meanwhile, David, the sixteen-year-old heir to the Collins fortune, has fallen in love with Jacqueline, a young girl living at the Old House who is the reincarnation of Angelique. David and Jacqueline are swept back in time to the prohibition era of the Twenties, where David uncovers the dark secrets of the Collins family history.

Most threatening of all, Dr. Nathanial Blair, an expert in the paranormal, has come to Collinwood because he suspects they are harboring a vampire. Fortunately, Barnabas Collins has returned to his coffin after a disastrous flirtation with life as a human. Nevertheless, what Blair discovers places the entire Collins family in jeopardy.