Arriving in Marquette for her freshman year at Northern Michigan University, Molly enrolls in Dr. Robinson's ecology studies class, hoping to learn more about the natural world and how to protect the planet from human impact. She befriends her classmates, Dr. Robinson's Crusoes, who share her love of hiking, camping, and building bonfires on the shores of Lake Superior.

Together, Molly and the Crusoes protest the development of Project ELF, a Navy program that is installing a series of extremely low-frequency transmitters across the Great Lakes. The US government claims Project ELF will help the country defend itself in the event of a nuclear invasion, but Upper Peninsula residents fear the communications lines will disrupt the natural environment that they hold sacred.

Initially preoccupied with the contingencies of freshman year--roommate problems, dormitory life, and dating--Molly begins to sense that the Project ELF protests may mask a more problematic dynamic between the students and faculty. As she struggles to find her purpose, Molly uncovers layers of lies and misunderstandings about campus life, Project ELF, and her time in Marquette that make her question her place in the community.

As in other notable campus novels, like Donna Tartt's The Secret History or Elif Batuman's The Idiot, Sharon Dilworth's To Be Marquette portrays an undergraduate narrator groping for meaning in a world where personal transformation takes place alongside conflicting cultural paradigms.