1America's favorite crime family is back. This time, the danger and challenges that face them are greater than ever. Violence in Mexico has caused the U.S. to shut down the border, thus severely restricting The Commission's drug supplies. The Commission must bow down to their old enemy, Cedras, the new leader of the Colombian cartels, in order to once again get its supplies from Colombia. The Reigns family's new cancer and HIV wonder drugs have turned out to be complete failures, thus resulting in massive lawsuits against Damian's Bio One pharmaceutical company. The Reigns family is now going broke in order to settle the massive class action lawsuit, and with no drug supplies to bring in more cash, the family's finances are in dire straights. Sensing weakness, The Commission now sees this as its opportunity to put the Reigns family back in its place. Cedras also sees this as an opportunity to wipe the Reigns family off the face of the Earth. And the Old Mafia, which has grown stronger once again, now sees its chance for revenge against the upstart Reigns family. With enemies coming out of the wood work, with Nathan and the FBI hot on their trail, with no drugs to bring in any money, and having to virtually bankrupt themselves to settle all of the lawsuits, the Reigns family is facing its toughest challenge to date. Can the family survive this massive onslaught against it? Or will this mean the end for America's most powerful crime family?