8Stitches is a romantic thriller set in Los Angeles in 2023 during post-pandemic times. Socializing has resurged and Ale (short for Alessandra), an ER nurse and sometimes waitress, meets a handsome security expert at a VIP party. Nicknamed "Striker" for his military background, Carlos Montoya also feels a flicker of interest for Ale.

At the same time, Ale's former high-school fling, Detective Jason O'Malley, slips back into her world. To complicate matters are the gangbangers Ale has grown close to while working at the hospital, not to mention her overprotective Italian family, the Ferrettis, who adopted her as a child.

Gorgeous and with a heart of gold, the perennially single Ale is soon over her head with everyone vying for her attention and affections. All these complicated relationships come crashing together as Ale unexpectedly finds herself in danger, not knowing who to trust.