Stay-at-home mom Kris loves her life and her family but she can't help but feel as though she's lost a little bit of herself. Sometimes it feels like she could burst out of her own skin. She's starving for attention, starving for an escape and starving to reclaim her own sense of identity and place in the world again.

On a rare girls' night out, Kris has a little too much to drink and gets roughed up and romanced by a hypnotic stranger. She goes home with a wounded shoulder and an equally wounded ego, and wakes up the following day with strange new cravings. With every day, Kris finds it more and more difficult to deny that something is terribly wrong with her.

With the help of a new friend, Kris soon learns that she'll have to make the biggest sacrifice of all if she wants to keep her family and herself intact. Girls Night Out is a fever dream dissection of how one bad decision and a lifetime of repression and regrets can lead to a spiral self-destruction.