2Lisinopril is used to treat high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. It is also used to treat heart failure and to improve survival after a heart attack. Lisinopril belongs to a class of drugs known as ACE inhibitors. It works by relaxing blood vessels so blood can flow more easily. The dosage is based on your medical condition and response to treatment. For children, the dosage is also based on weight. To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully. What Conditions does Lisinopril Treat? - kidney disease from diabetes - chronic heart failure - migraine prevention - high blood pressure - a heart attack - kidney problem caused by body tissue disease-scleroderma - chronic kidney disease with albuminuria