Preacher Jesse Custer's dark journey to find God, accompanied by his gun-toting girlfriend and Irish vampire buddy, continues in this third volume. During some down time, Jesse Custer faces an enemy from the past, who seeks vengeance for his father's death. Also includes a story spotlighting the Saint of Killers and a standalone tale starring Cassidy, the vampire.

This volume collects Preacher #34-40, Preacher Special: One Man's War, Preacher Special: The Good Old Boys, Preacher Special: The Story of You-Know-Who.