In a world where monsters called Yoma prey on humans and live among them in disguise, humanity's only hope is a new breed of warrior known as Claymores. Half human, half monster, these silver-eyed slayers possess supernatural strength but are condemned to fight their savage impulses or lose their humanity completely.

Fearing that she's no match for the deadly Claymore named Ophelia, Clare spirits her companion Raki away to relative safety. But no matter how far they run, they won't be able to escape Ophelia's heightened senses. And now that Ophelia knows that Clare has awakened, she will not rest until she has destroyed Clare.