In a world where monsters called Yoma prey on humans and live among them in disguise, humanity's only hope is a new breed of warrior known as Claymores. Half human, half monster, these silver-eyed slayers possess supernatural strength but are condemned to fight their savage impulses or lose their humanity completely.

Clare and a group of Claymores are sent to the north to battle a group of Yoma that have banded together under the command of Isley, a powerful Awakened Being. When the warriors arrive, they find their new enemies to be unusually dangerous. They are incredibly strong, well-organized, and seem to have a plan to dominate the entire region. Will the Claymores be able to stop this monstrous army?