In a world where monsters called Yoma prey on humans and live among them in disguise, humanity's only hope is a new breed of warrior known as Claymores. Half human, half monster, these silver-eyed slayers possess supernatural strength but are condemned to fight their savage impulses or lose their humanity completely.

In the northern town of Pieta, Clare and a force of Claymores battle a troupe of Awakened Ones to prevent them from advancing south. Their orders are to hold off the evil horde at all costs, while the Organization prepares a secret weapon. Clare and her comrades realize that theirs is a suicide mission. As their friends fall one by one, the warriors band together to make their last stand.