In Tsutomu Nihei's nightmare vision of the future, the N5S virus has swept across the earth, turning most of the population into zombie-like drones. Zoichi Kanoe, an agent of Toa Heavy Industry, is humanity's last hope, and he's not even human! With the help of Fuyu, a digitized intelligence built into the computer system of his Heavy Dual Coil motorcycle, Zoichi's search for the key to salvation will take him on a journey across surreal landscapes and hurl him into battle against mind-bending evil. Prepare yourself for the ultimate trip--prepare yourself for the world of BIOMEGA.

After capturing Eon Green, DRF forces are amassing around Toa Heavy Industry headquarters and have taken Dr. Kurokawa and his daughter into custody. Zoichi must attempt a rescue--Dr. Kurokawa's laboratory may yield critical information on Eon Green. Elsewhere, Toa Heavy Industry agent Nishu Mizunoe searches for Kozlov Grebnev and the secrets he knows about the DRF's research, origins and their apocalyptic plan for the entire human race!