In Tsutomu Nihei's nightmare vision of the future, the N5S virus has swept across the earth, turning most of the population into zombie-like drones. Zoichi Kanoe, an agent of Toa Heavy Industry, is humanity's last hope, and he's not even human! With the help of Fuyu, a digitized intelligence built into the computer system of his Heavy Dual Coil motorcycle, Zoichi's search for the key to salvation will take him on a journey across surreal landscapes and hurl him into battle against mind-bending evil. Prepare yourself for the ultimate trip--prepare yourself for the world of BIOMEGA.

The Data Research Foundation's plan to transform humanity and the earth itself accelerates as the DRF locates another executor of the apocalypse, General Narein. Toa Heavy Industry agents Zoichi Kanoe and Nishu Mizunoe haven't given up yet, and Zoichi continues his journey to Maximum Security Containment Facility 3 in search of Eon Green. To stop them, the DRF is bringing out its heaviest hitters... The battle lines are drawn, and Armageddon never looked so good!