In Tsutomu Nihei's nightmare vision of the future, the N5S virus has swept across the earth, turning most of the population into zombie-like drones. Zoichi Kanoe, an agent of Toa Heavy Industry, is humanity's last hope, and he's not even human! With the help of Fuyu, a digitized intelligence built into the computer system of his Heavy Dual Coil motorcycle, Zoichi's search for the key to salvation will take him on a journey across surreal landscapes and hurl him into battle against mind-bending evil. Prepare yourself for the ultimate trip--prepare yourself for the world of BIOMEGA.

Seeking to remake the world, Niarudi--the matriarch of the DRF and the mastermind behind the N5SV drone epidemic--has unleashed the Reverse Morphic Polymer. But unplanned contact during the transformation reduces the planet to ruin. In its place a giant cordlike world appears, complete with its own population and ecosystem. Enveloped by the change, Zoichi, Nishu and the others set out into this bizarre new world to thwart Niarudi's plans. The strange inhabitants of the cord bring stranger revelations still, and the struggle to control the future of humanity turns toward its final conflict!