In an alchemical ritual gone wrong, Edward Elric lost his arm and his leg, and his brother Alphonse became nothing but a soul in a suit of armor. Equipped with mechanical "auto-mail" limbs, Edward becomes a state alchemist, seeking the one thing that can restore his and his brother's bodies...the legendary Philosopher's Stone.

As the battle for Central City rages on, Alphonse faces off against Pride and Kimblee with the aid of a Philosopher's Stone. Can he come up with a plan to take down these two dangerous foes? Meanwhile, Ed and his friends run into Envy below the city. When Roy Mustang learns the truth about Hughes's murder, will he be consumed by hatred and do the unthinkable...?