In a world where monsters called Yoma prey on humans and live among them in disguise, humanity's only hope is a new breed of warrior known as Claymores. Half human, half monster, these silver-eyed slayers possess supernatural strength but are condemned to fight their savage impulses or lose their humanity completely.

Priscilla relentlessly pursues Clare's destruction, while Deneve and Helen remain just as determined to protect her. But when the combined form of Luciela and Rafaela attacks, Clare and her cohorts are pulled into the twisting mass. Meanwhile, in Rabona, Miria heads east to destroy the Organization. She encounters Rubel and his secret weapons: mysterious warrior twins who may be Alicia and Beth's successors, as well as the Organization's number 10--a deadly fighter who can read Miria's mind.