In a world where monsters called Yoma prey on humans and live among them in disguise, humanity's only hope is a new breed of warrior known as Claymores. Half human, half monster, these silver-eyed slayers possess supernatural strength but are condemned to fight their savage impulses or lose their humanity completely.

A battle begins between rebel Claymore warriors and the Organization that created them. When the team of seven notorious rebel fighters is joined by an army of newly minted soldiers loyal to rebel leader Miria, it seems their victory is a foregone conclusion. Then the Organization releases its newest secret weapon: reanimated high-level warriors from past generations of Claymores.