In a world where monsters called Yoma prey on humans and live among them in disguise, humanity's only hope is a new breed of warrior known as Claymores. Half human, half monster, these silver-eyed slayers possess supernatural strength but are condemned to fight their savage impulses or lose their humanity completely.

Rebel warrior Miria penetrates the headquarters of the secret Organization that created her, discovering the appalling truth about Yoma. Meanwhile, human warrior Raki joins the Claymores on the battlefield and seems closer than ever to his goal of reuniting with Clare, his Claymore companion. Yet the cycle of violence cannot be stopped--an epic battle is brewing and Priscilla, a powerful force for evil, is back in the fight!