Macaskill demonstrates that attempts to read the Bible with reference to autism are often deficient because they move too quickly from the study of particular texts to claims about the condition and how it should be viewed. This leads some Christians to see autism as something that should be healed or even exorcised. Macaskill instead invites readers to struggle with the biblical canon, in ways shaped by the traditions of the early church, to a process of interpretation that calls upon the church, following Christ's teaching, to cherish those who experience autism as part of the diverse gifting of Christ's body. Accordingly, he calls churches to consider the implications of autism in their congregations and to explore how best to accommodate the particular needs of autistic people in public worship and pastoral care, while valuing their distinctive contribution. In short, Macaskill challenges the church to "think biblically" about autism.
Autism and the Church teaches readers that those with autism belong to the church, demonstrating that, if responsibly read, the Bible provides a resource that enables the church to recognize the value of those with autism. Macaskill shows how the Bible can help both individuals and church bodies flourish, even as the church deals faithfully with the opportunities and challenges that come with understanding autism. He writes as a biblical scholar intimately familiar with the experience of autism, dealing honestly with the real difficulties that can accompany the condition, while challenging misconceptions.