Matthew 28:18-20, Mark 16:15, Luke 24:7-9, John 20:21 and Acts 1:8, is to be a continuous command to follow, in order to reach the different people groups of the world including the professionals in North America metropolises. Based on academic studies, which included surveys sent to Christian leaders in church congregations and professionals in the secular workplace, along with the associated literature research in the subject, this book reviews the Great Commission call to reach professionals in metropolises, examining their lifestyle environment, past and current trends to reach them, biblical principles that can turn into methods to be used in their outreach and the practical implication analysis. This work will encourage all believers to pursue the presence of God in order to fulfill their callings and purposes in their lives. Doctor Ralph Baeza is a professional consulting engineer, and church minister and pastor in the Southeast Florida region of North America. He has worked in different Church Congregation positions and ministries during the past forty years and, as a career professional engineer in the consulting building industry, for over three decades. Doctor Baeza completed his Doctor of Ministry program with concentration in Evangelism and Church Growth at Liberty Baptist Theological Seminary. His thesis work focused in Church Ministries to reach professionals in North America metropolises and beyond.