An unfortunate accident with an Apple drives Bunny from Bunnyland to Elsewhere. Every letter in the alphabet is represented in Bunny's journey, through what he eats (Greens), to whom he meets (Insects, Jay, Kitten, Lizard), and then a little sleep (Nap), to Tripping back to town, right side Up and Up-side-down.

The creation of The ABC Bunny was a Gág family affair, with sister Flavia composing the "ABC Song," included in this faithful edition; brother Howard penning the lettering; and Wanda writing and illustrating the story.