Mary Watson knows just how she feels, though her focus is less on sick women than on missing boys—the skinny, grubby, poor ones that nobody wanted in the first place. Sherlock Holmes isn't interested in either issue; he and Dr. Watson have more important puzzles to solve. So once again, it is left to Mary and Mrs. Hudson to help the truly vulnerable, to draw lines between the dying women and the disappearing boys, and to follow those lines to their grim conclusion.