A strong and proud boxer, he spends his early days with a loving family in a public housing complex in Washington, DC. Abruptly, he is taken away by an abusive, alcoholic man, plunging Buster into a challenging, nightmarish existence. Over the course of his life, he will experience homelessness, tragedy, a harrowing stay in a shelter, and acts of kindness, including his adoption by an older gentleman grieving the death of his wife.

At his peak, Buster lives with a young marijuana dealer who runs a profitable but dangerous business in the city. Along the way, Buster befriends other dogs and witnesses the best and worst aspects of humanity. As the seasons change, and change again, he begins to understand the finality of existence and in turn learns to appreciate the gift of life.