Sam's Mesa is a flowing tale of one man's life beginning in his teens, covering several escapades and losses within the family status. He acquires a riding mule under strange circumstances, which is the ghost mule of the Sioux Indian Nation. While in his time of grief, the mule takes him to the magic mesa of the Indians. Here, he regains his love of people through the saving of a young lady. Then he discovers that the mesa makes strange music that the Indians regard as sacred.