When sixteen-year-old Shae meets Cam, who is new to their small town in West Virginia, she thinks she has found someone who is everything she has ever wanted in a companion. The two become fast friends, and then more. And when Shae ends up pregnant, Cam begins a different transition--trying on clothes that Shae can no longer fit into and using female pronouns. Shae tries to be fully supportive as Cam becomes the person she wants and needs to be.

After a traumatic C-section and the birth of their daughter, Eva, Shae is given opioids to manage the intense pain. During the first year of Eva's life, Shae's dependence shifts from pain management to addiction, and her days begin to revolve around getting more pills. In the heart of West Virginia, opioids are dispensed as freely as candy, and Shae is just one of many to fall victim to addiction. Meanwhile, as Cam continues to transition, she embraces new relationships and faces the reality of being a trans woman in rural America.

Shae is as much about these two young women as it is about the home they both love despite its limitations. Following the acclaimed Sugar Run and Perpetual West, this is Mesha Maren's most intense and intimate novel yet.