For Jodi Wexler, a Florida doctor with a flourishing practice, only one thing's missing: the chance to spend more time getting to know her eight-year-old granddaughter, Macallan.

When Jodi's restauranteur daughter asks her to watch Macallan in the Berkshires while she takes care of some business out of town, Jodi can't say yes fast enough. Neither Jodi's podiatric patients nor her just-fired, suddenly retired husband can keep her away. But when Jodi arrives, she discovers she's not the only grandma at Lisa's house. Lisa's mother-in-law, Di--a hard-nosed real estate agent--has moved into the house. What's more, there's Grannie Annie, the twenty-seven-year-old girlfriend of Lisa's oddball father-in-law. They're not the only surprises. Lisa's marriage is faltering even as her new restaurant is taking off.

As the competition for Macallan's attention among the three "grandmas" increases, Lisa drops a bomb about her life that changes everything. Under pressure, and determined to help her daughter, Jodi must choose her next step. Her decision surprises everyone--Jodi, most of all.