The Tragic Muse is a novel by Henry James, first published as a serial in The Atlantic Monthly in 1889-1890 and then as a book in 1890. This wide, cheerful panorama of English life follows the fortunes of two would-be artists: Nick Dormer, who throws over a political career in his efforts to become a painter, and Miriam Rooth, an actress striving for artistic and commercial success. A cast of supporting characters help and hinder their pursuits.

Nick Dormer wants to pursue a career in painting instead of his family's traditional role in British politics. This upsets his family and particularly his lady friend, Julia Dallow, a beautiful but demanding woman deeply involved in political campaigns. But Nick's old Oxford friend Gabriel Nash encourages him to follow his desire to become an artist. Despite his misgivings Nick goes through an election campaign, supported by Julia, and wins a seat in Parliament. He proposes marriage to Julia but they agree to wait.

Meanwhile, Nick's cousin Peter Sherringham, a rising young man in the British diplomatic service, encounters a young actress, Miriam Rooth, in Paris. He falls in love with Miriam, who shows great energy but is a woefully raw talent. Peter introduces Miriam to French acting coach Madame Carre, and Miriam begins to improve her acting technique greatly.

Nick seeks to become an artist and resigns from Parliament. He thus loses a large bequest from his political patron, Mr. Carteret. Nick becomes a full-time painter, and when Miriam comes to London in search of theatrical success, she sits to Nick for her portrait as "the tragic muse." Julia finds the two together in the studio. Although nothing improper is going on, Julia suddenly and bitterly realizes that Nick is dedicated to art and will never return to politics.

Peter proposes marriage to Miriam, but she refuses. Peter accepts a diplomatic assignment in Central America. Miriam eventually triumphs as an actress, especially as Juliet. Peter returns to London to see her debut in this role, and again proposes to her; but she is already married to Basil Dashwood, her business manager. The novel ends with a suggestion that Nick and Julia may eventually marry, after all.