Hiding from Sherlock and her other brother, Mycroft, who want to place her in a boarding school following their mother's disappearance, Enola has reinvented herself as Ivy Meshle, secretary to the fictitious Dr. Ragostin, specialist in finding missing persons. Her new client? None other than Sherlock's friend, Dr. John Watson His mission: to employ Dr. Ragostin to find the missing Enola She decides to take the case, only so she can keep tabs on Sherlock's every move to locate her.

Yet Ivy Meshle is just one of Enola's disguises. In her search for a missing teenager, the Lady Cecily Alistair, she alternately poses as Lady Ragostin, wife of her non-existent employer, and as Sister, the kindly nun who braves the dangerous nighttime alleys to bring comfort to the homeless. All the time she and Sherlock play a game of cat and mouse.

This beautifully drawn graphic novel adaptation also includes a portfolio of pages from Enola's secret notebook.