Ten years of frustration and heartbreak caring for his son John, born with a catastrophic heart defect, have convinced Rick Morrow that the world is stacked against his family. And on what should be the best day of their life -- the day when John will finally get a new heart - an even worse nightmare begins, when the helicopter carrying the heart crashes, destroying the heart and the hopes of the Morrow family.

Rick's heartbreak turns to rage as he begins to suspect that the accident was no accident at all. His pursuit of the truth puts him on a collision course with the giant Cera Corporation and the powerful family that runs it, who have an agenda of their own and will stop at nothing to make it come true. The escalating conflict threatens Rick's reputation, his safety and even his marriage. It reaches its gut-wrenching climax with Rick and his wife Mary facing and even more terrible question; will they sacrifice all they believe in to save their own son, at a cost almost too high to imagine?

Heartless forces us to ask ourselves the most basic of questions: how far should we go to save the life of someone we love? And what makes a life matter in the first place?