The story follows the adventures of a nameless hidalgo who reads so many chivalric romances that he loses his sanity and decides to set out to revive chivalry, undo wrongs, and bring justice to the world, under the name Don Quixote. He recruits a simple farmer, Sancho Panza, as his squire, who often employs a unique, earthy wit in dealing with Don Quixote's rhetorical orations on antiquated knighthood. Don Quixote, in the first part of the book, does not see the world for what it is and prefers to imagine that he is living out a knightly story.

Published in two volumes, in 1605 and 1615, Don Quixote is considered one of the most influential works of literature from the Spanish Golden Age and the entire Spanish literary canon. As a founding work of modern Western literature and one of the earliest canonical novels, it regularly appears high on lists of the greatest works of fiction ever published, such as the Bokklubben World Library collection that cites Don Quixote as authors' choice for the "best literary work ever written."