The fentanyl crisis just got a lot worse. Drug lord Diego Garcia has begun trafficking a new fentanyl-laced pill that has quadrupled overdose deaths in Nevada and California. DEA special agent Antonio Vega has a plan to capture Garcia and shut down his criminal enterprise before his designer drug goes nationwide and kills hundreds of thousands of Americans.

Meanwhile, Elena Sanchez, Garcia's wife, incarcerated for drug trafficking and the attempted murder of a cop, escapes from prison and begins a perilous journey through Mexico to her husband, who is hiding away in his heavily guarded secret mountain estate. Former New Orleans homicide detective Jo Crowder agrees to help Sanchez evade the Mexican authorities, rival cartels, and street gangs, who pursue them every step of the way.