In That Time of Year, Garrison Keillor looks back on his life and recounts how a Brethren boy with writerly ambitions grew up in a small town on the Mississippi in the 1950s and, seeing three good friends die young, turned to comedy and radio. Through a series of unreasonable lucky breaks, he founded A Prairie Home Companion and put himself in line for a good life, including mistakes, regrets, and a few medical adventures. PHC lasted forty-two years, 1,557 shows, and enjoyed the freedom to do as it pleased for three or four million listeners every Saturday at 5 p.m. Central. He got to sing with Emmylou Harris and Renée Fleming and once sang two songs to the U.S. Supreme Court. He played a private eye and a cowboy, gave the news from his hometown, Lake Wobegon, and met Somali cabdrivers who'd learned English from listening to the show. He wrote bestselling novels, won a Grammy and a National Humanities Medal, and made a movie with Robert Altman with an alarming amount of improvisation.

He says, "I was unemployable and managed to invent work for myself that I loved all my life, and on top of that I married well. That's the secret, work and love. And I chose the right ancestors, impoverished Scots and Yorkshire farmers, good workers. I'm heading for eighty, and I still get up to write before dawn every day."