Takashi Natsume can see the spirits and demons that hide from the rest of humanity. He has always been set apart from other people because of his gift, drifting from relative to relative, never fitting in. Now he is a troubled high school student who has come to live in the small town where his grandmother grew up. And there he discovers that he has inherited more than just the Sight from the mysterious Reiko.

Nyanko Sensei is missing, and the only clue to his whereabouts is a shard of pottery painted with calico markings! Following the urgings of a dream sent by the shard, Natsume travels to a local kiln and finds that there's far more going on than just a lost kitty yokai.